全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMR09284G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PINK1 antibody.
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分子量 |
62769 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm, cytosol
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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免疫原 |
Unknown aa
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靶點(diǎn) |
Recombinant PINK1 protein was used to produced this monoclonal antibody.
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克隆號 |
38CT20.8.5
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亞型 |
IgG1
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基因ID |
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UniProt ID |
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功能 |
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582).
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總結(jié) |
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
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形式 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, IF, E
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稀釋方法 |
WB~~1:100~500
IHC-P~~1:50~100
IF~~1:25
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別名 |
Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1
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圖像 |
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說明書 |
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數(shù)量 |
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