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ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) Antibody - With BSA and Azide

貨號 貨期 規(guī)格 / 價格 詢價
APR07218G 50 μg / ¥3950

ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) Antibody - With BSA and Azide

品牌

Leading Biology

貨號

APR07218G

產品分類

Monoclonal Antibodies

研究領域

產品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) antibody - With BSA and Azide.

分子量

ACTH is ~5kDa, and the POMC precursor is ~30kDa.

細胞定位

Antigen Cellular Localization: Secreted.

宿主

Mouse

種屬反應性

Human, Mouse, Rat

靶點

Synthetic peptide corresponding to aa1-24 of human ACTH

克隆號

2F6

亞型

IgG1, kappa

基因ID

UniProt ID

功能

ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates.

總結

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

形式

0.5 ml at 200ug/ml with BSA and azide

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應用

WB, IHC, FC, IP, E

別名

Pro-opiomelanocortin, POMC, Corticotropin-lipotropin, NPP, Melanotropin gamma, Gamma-MSH, Potential peptide, Corticotropin, Adrenocorticotropic hormone, ACTH, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin, POMC

說明書

數量

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