p190-B RhoGAP Antibody

APR17708G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17708G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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p190-B RhoGAP Antibody

品牌	Leading Biology	貨號(hào)	APR17708G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality p190-B RhoGAP antibody.
分子量	172460 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues in human p190-B RhoGAP was used as immunogen.
克隆號(hào)	EP489Y
通用名	RHOGAP5
基因ID	394
UniProt ID	Q13017
功能	GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.
總結(jié)	The p190 Rho GTPase activating protein RhoGAP) family includes two closely related proteins, p190-A and p190-B. p190-B contains an N-terminal GTPase domain and a C-terminal Rho-GAP domain (1). p190-B can be directly phosphorylated on a single identified tyrosine residue by the activated insulin and IGF-1 receptors. This phosphorylation causes p190-B to translocate to the lipid rafts of the plasma membrane, where it can facilitate the inactivation of the Rho GTPase. P190-B also has been shown to be tyrosine phosphorylated by c-Src and v-Src. Additionall; the GAP domain of p190-B as shown to attenuate signal-transducing activity of Rac, Rho and CDC42 (2-3).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:500 IHC~~1:100~250
別名	Rho GTPase-activating protein 5, Rho-type GTPase-activating protein 5, p190-B, ARHGAP5, RHOGAP5
圖像	A. Western blot analysis of anti-p190-B RhoGAP RabMAb (Cat. APR17708G) 1:500 dilution A-Hela B-Jurkat C-MCF-7 D-K562 E-A431 F-293 G-NIH 3T3 H-PC12 B. Immunohistochemical analysis of paraffin-embedded human stomach carcinoma using anti-p190-B RhoGAP RabMAb (Cat. APR17708G).
說(shuō)明書	Product Datasheet Protocol
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