全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR17722G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality P2Y6 antibody.
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分子量 |
36429 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
A synthetic peptide corresponding to residues in human P2Y6 was used as an immunogen.
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克隆號(hào) |
EPR3816
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基因ID |
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UniProt ID |
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功能 |
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
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總結(jié) |
P2Y6 is a multi-pass membrane protein and P2Y receptor, belonging to the family of G-protein coupled receptor 1 (1). The P2Y family is composed of eight cloned and functionally defined subtypes, including five that are present in human tissues (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) (2). P2Y6 is expressed in human spleen, placenta, thymus, intestine, and blood leukocytes and is a receptor for extracellular UDP, UTP and ADP (1). It contributes to microglia activation and their later phagocytosis in CNS, and in the immune system, it participates in the secretion of interleukin (IL)-8 from monocytes and macrocytes. It has been suggested that P2Y6 may play a role in neuroinflammation in CNS (3).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC
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稀釋方法 |
WB~~1:20000~50000
IHC~~1:100~250
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別名 |
P2Y purinoceptor 6, P2Y6, P2RY6
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圖像 |
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說明書 |
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數(shù)量 |
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