Apaf-1 Antibody [2E10]

APG01900G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APG01900G		0.1 mg / ￥6950

大規(guī)格詢(xún)價(jià)

2 Images

訂購(gòu)信息

安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
Inquiry@annoron.com

全國(guó)授權(quán)代理商

Apaf-1 Antibody [2E10]

品牌	Leading Biology	貨號(hào)	APG01900G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Apaf-1 antibody [2E10] .
分子量	130 kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm.
宿主	Mouse
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	APAF1;
克隆號(hào)	2.00E+10
通用名	KIAA0413
基因ID	317
UniProt ID	O14727
功能	Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
總結(jié)	Apaf-1 Monoclonal Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
圖像	Western blot analysis of Apaf1 in K562 cell lysate with Apaf1 antibody at (A) 0.25 and (B) 0.5 mg/mL. Immunohistochemistry of Apaf1 in K562 cells with Apaf1 antibody at 0.5 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
數(shù)量

加入購(gòu)物車(chē) 詢(xún)價(jià)

上一產(chǎn)品：Apaf-1 Antibody [5E11] 下一產(chǎn)品：CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant

熱銷(xiāo)產(chǎn)品

相關(guān)產(chǎn)品

選擇	品牌	貨號(hào)	產(chǎn)品名稱(chēng)	規(guī)格	分類(lèi)	研究領(lǐng)域	說(shuō)明書(shū)	數(shù)量	目錄價(jià)
1	Leading Biology	APG01369G	VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide	100 μg	Monoclonal Antibodies				￥4950.00	訂購(gòu) 詢(xún)價(jià)
2	Leading Biology	AMM07627G	RIN2 Antibody (monoclonal) (M01)	100 μg	Monoclonal Antibodies				￥4950.00	訂購(gòu) 詢(xún)價(jià)
3	Leading Biology	APR15980G	FGG Antibody	100 μl	Monoclonal Antibodies				￥5450.00	訂購(gòu) 詢(xún)價(jià)
4	Leading Biology	AMM05161G	GOB5 / CLCA1 Antibody (clone 1C4)	50 μg	Monoclonal Antibodies				￥5450.00	訂購(gòu) 詢(xún)價(jià)
5	Leading Biology	APR17667G	ORAI1 Antibody [3F6H5]	0.1 mg	Monoclonal Antibodies				￥6950.00	訂購(gòu) 詢(xún)價(jià)
6	Leading Biology	APR11118G	HIV-1 p24 Antibody [7F4] (biotin)	0.1 mg	Monoclonal Antibodies				￥6950.00	訂購(gòu) 詢(xún)價(jià)