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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Functional Rab1-GTP Antibody, mAb (recombinant)品牌 |
Leading Biology | 貨號 |
APR16044G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Functional Rab1-GTP antibody, mAb (recombinant).
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分子量 |
22678 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane-associated and cytosolic forms
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宿主 |
Purified From?HEK 293 Cell?culture Supernatant.
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種屬反應(yīng)性 |
Human, Mouse, Rat, Dog
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靶點(diǎn) |
Recognizes human, mouse, rat and dog Rab1a-GTP and Rab1b-GTP.
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克隆號 |
ROF7
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亞型 |
Human IgG2λ
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通用名 |
RAB1
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基因ID |
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UniProt ID |
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功能 |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
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總結(jié) |
Rab1 (Ypt1 in yeast) is a small GTPase that plays a well-established role in mediating ER-to-Golgi protein transport in both yeast and mammalian cells. Rab1 recruits effector proteins to budding COPII vesicles at the ER, forming cis-SNARE complexes that promote targeting to and fusion of these vesicles with the cis-Golgi. Rab1 is also involved in COPI vesicle formation and other distinct transport pathways, including ER-to-Golgi intermediate compartment (ERGIC)-to-cell periphery trafficking. Recently Rab1 has been shown to function in antimicrobial autophagy (autophagosome formation), as well as other forms of autophagy in mammalian cells in a way independent of ER-to-Golgi trafficking.
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形式 |
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
ICC, IP
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別名 |
Ras-related Protein Rab-1
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圖像 |
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說明書 |
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數(shù)量 |
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