CLDN1 / Claudin 1 Antibody (clone 1C5-D9)

APR15473G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR15473G		50 μg / ￥5450

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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CLDN1 / Claudin 1 Antibody (clone 1C5-D9)

品牌	Leading Biology	貨號(hào)	APR15473G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLDN1 / Claudin 1 antibody (clone 1C5-D9).
分子量	23kDa
細(xì)胞定位	Antigen Cellular Localization: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
宿主	Mouse
種屬反應(yīng)性	Human
克隆號(hào)	1C5-D9
通用名	CLD1, SEMP1
基因ID	9076
UniProt ID	O95832
功能	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
總結(jié)	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	IHC-P (5 μg/ml)
別名	Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1
圖像	CLDN1 monoclonal antibody, clone 1C5-D9. Western blot of CLDN1 expression in PRC/PRF/5. Anti-CLDN1 / Claudin 1 antibody IHC of human pancreas.
說(shuō)明書	Product Datasheet Protocol
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CLDN1 / Claudin 1 Antibody (clone 1C5-D9)