MAPK10 Antibody

APR08324G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR08324G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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MAPK10 Antibody

品牌	Leading Biology	貨號	APR08324G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MAPK10 antibody.
分子量	53kDa
細胞定位	Antigen Cellular Localization: Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity).
宿主	Mouse
種屬反應(yīng)性	Human, Mouse
克隆號	10E4A4
亞型	IgG1
通用名	JNK3, JNK3A, PRKM10, SAPK1B
基因ID	5602
UniProt ID	P53779
功能	Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, ICC, E
稀釋方法	WB~~1/500 - 1/2000 IF~~1/200 - 1/1000
別名	Mitogen-activated protein kinase 10, MAP kinase 10, MAPK 10, 2.7.11.24, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAPK10, JNK3, JNK3A, PRKM10, SAPK1B
圖像	Figure 1: Western blot analysis using MAPK10 mouse mAb against NIH/3T3 (1) and SKN-SH (2) cell lysate. Figure 2: Immunofluorescence staining of methanol-fixed A431 (left) and Hela (right) cells showing cytoplasmic and membrane localization.
說明書	Product Datasheet Protocol
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