JARID2 Antibody

APR12447G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR12447G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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JARID2 Antibody

品牌	Leading Biology	貨號	APR12447G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality JARID2 antibody.
分子量	139kDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus {ECO:0000255\|PROSITE- ProRule:PRU00355, ECO:0000255\|PROSITE-ProRule:PRU00537, ECO:0000269\|PubMed:20075857}. Note=Colocalizes with the PRC2 complex on chromatin
宿主	Mouse
種屬反應(yīng)性	Human
克隆號	7H1B3
亞型	IgG2a
通用名	JMJ
基因ID	3720
UniProt ID	Q92833
功能	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, FC, ICC, E
稀釋方法	E~~1/10000 WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400
別名	Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2, JMJ
圖像	Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Figure 2:Western blot analysis using JARID2 mAb against human JARID2 (AA: 1097-1246) recombinant protein. (Expected MW is 42.7 kDa) Figure 3:Western blot analysis using JARID2 mAb against HEK293 (1) and JARID2 (AA: 1097-1246)-hIgGFc transfected HEK293 (2) cell lysate.
說明書	Product Datasheet Protocol
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