SIRT6 Antibody

APR09967G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR09967G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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SIRT6 Antibody

品牌	Leading Biology	貨號	APR09967G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIRT6 antibody.
分子量	39.1kDa
細胞定位	Antigen Cellular Localization: Nucleus, nucleoplasm. Note=Predominantly nuclear Associated with telomeric heterochromatin regions
宿主	Mouse
種屬反應(yīng)性	Human
克隆號	2G1E8
亞型	IgG1
通用名	SIR2L6
基因ID	51548
UniProt ID	Q8N6T7
功能	NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, FC, ICC, E
稀釋方法	E~~1/10000 WB~~1/500 - 1/2000
別名	NAD-dependent protein deacetylase sirtuin-6, 3.5.1.-, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6
圖像	Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng); Figure 2:Western blot analysis using SIRT6 mAb against human SIRT6 (AA: 141-250) recombinant protein. (Expected MW is 38 kDa) Figure 3:Western blot analysis using SIRT6 mAb against HEK293 (1) and SIRT6 (AA: 141-250)-hIgGFc transfected HEK293 (2) cell lysate.
說明書	Product Datasheet Protocol
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