SIRT4 Antibody

APR09959G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR09959G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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SIRT4 Antibody

品牌	Leading Biology	貨號	APR09959G
產(chǎn)品分類	Monoclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIRT4 antibody.
分子量	35.2kDa
細胞定位	Antigen Cellular Localization: Mitochondrion matrix {ECO:0000255\|HAMAP- Rule:MF_03161, ECO:0000269\|PubMed:16079181, ECO:0000269\|PubMed:16959573, ECO:0000269\|PubMed:17715127}
宿主	Mouse
種屬反應性	Human
克隆號	6A12D7
亞型	IgG1
通用名	SIR2L4
基因ID	23409
UniProt ID	Q9Y6E7
功能	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IHC, FC, ICC, E
稀釋方法	E~~1/10000 WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400
別名	NAD-dependent protein deacetylase sirtuin-4 {ECO:0000255\|HAMAP-Rule:MF_03161}, 3.5.1.- {ECO:0000255\|HAMAP-Rule:MF_03161}, NAD-dependent ADP-ribosyltransferase sirtuin-4 {ECO:0000255\|HAMAP-Rule:MF_03161}, 2.4.2.- {ECO:0000255\|HAMAP-Rule:MF_03161}, Regulatory protein SIR2 homolog 4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIR2-like protein 4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIRT4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIR2L4
圖像	Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng); Figure 2:Western blot analysis using SIRT4 mAb against human SIRT4 (AA: 215-314) recombinant protein. (Expected MW is 37 kDa) Figure 3:Western blot analysis using SIRT4 mAb against HEK293 (1) and SIRT4 (AA: 215-314)-hIgGFc transfected HEK293 (2) cell lysate.
說明書	Product Datasheet Protocol
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