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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > KRT17 / CK17 / Cytokeratin 17 Antibody (clone E3)品牌 |
Leading Biology | 貨號(hào) |
APR17065G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KRT17 / CK17 / Cytokeratin 17 antibody (clone E3).
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分子量 |
48kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Rat
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靶點(diǎn) |
Reacts with cytokeratin 17 in basal layers of pseudo-stratified and transitional epithelia.
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克隆號(hào) |
E3
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基因ID |
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UniProt ID |
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功能 |
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
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總結(jié) |
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, ICC, IHC-Fr, Flo
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稀釋方法 |
Flo (1:25-1:200), IHC-Fr (1:25-1:200), IHC-P (10 μg/ml), WB (1:100-1:1000) ,
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別名 |
Keratin, type I cytoskeletal 17, 39.1, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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