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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > TRPM7 Antibody (aa1817-1863, clone S74-25)品牌 |
Leading Biology | 貨號(hào) |
APR13819G |
產(chǎn)品分類(lèi) |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRPM7 antibody (aa1817-1863, clone S74-25).
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分子量 |
213kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
Detects ~220 kD protein. No cross reactivity with TrpM6.
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克隆號(hào) |
S74-25
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通用名 |
CHAK1, LTRPC7
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基因ID |
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UniProt ID |
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功能 |
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
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總結(jié) |
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, IF, ICC, IP
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稀釋方法 |
ICC (0.1-1 μg/ml), IHC-P (5 μg/ml), IP (1-10 μg/ml), WB (1-10 μg/ml) ,
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別名 |
Transient receptor potential cation channel subfamily M member 7, 2.7.11.1, Channel-kinase 1, Long transient receptor potential channel 7, LTrpC-7, LTrpC7, TRPM7, CHAK1, LTRPC7
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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