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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Osteoprotegerin / OPG Antibody (aa20-37, clone 98A1071)品牌 |
Leading Biology | 貨號 |
APR08890G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Osteoprotegerin / OPG antibody (aa20-37, clone 98A1071).
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分子量 |
46kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
A peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human OPG was used to immunize mice. The specificity was tested on recombinant OPG by western blot analysis.
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克隆號 |
98A1071
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通用名 |
OCIF, OPG
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基因ID |
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UniProt ID |
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功能 |
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
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總結(jié) |
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P
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稀釋方法 |
IHC-P (5 μg/ml)
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別名 |
Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, OCIF, OPG
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圖像 |
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說明書 |
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數(shù)量 |
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