ERBB2 Antibody

APR15859G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR15859G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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ERBB2 Antibody

品牌	Leading Biology	貨號	APR15859G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ERBB2 antibody.
分子量	180kDa
細胞定位	Antigen Cellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1 Isoform 3: Cytoplasm. Nucleus.
宿主	Mouse
種屬反應(yīng)性	Human
克隆號	6C2
亞型	IgG1
通用名	HER2, MLN19, NEU, NGL
基因ID	2064
UniProt ID	P04626
功能	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, FC, E
稀釋方法	WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 FC~~1/200 - 1/400
別名	Receptor tyrosine-protein kinase erbB-2, 2.7.10.1, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, HER2, MLN19, NEU, NGL
圖像	Figure 1: Western blot analysis using ERBB2 mouse mAb against SKBR3 (1) and MCF-7 (2) cell lysate. Figure 2: Immunohistochemical analysis of paraffin-embedded galactophore tumour using ERBB2 mouse mAb with DAB staining Figure 3: Flow cytometric analysis of MCF-7 cells using ERBB2 mouse mAb (green) and negative control (purple).
說明書	Product Datasheet Protocol
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