VHL Antibody (monoclonal) (M01)

APR10724G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR10724G		100 μg / ￥4950

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安諾倫（北京）生物科技有限公司

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VHL Antibody (monoclonal) (M01)

品牌	Leading Biology	貨號(hào)	APR10724G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality VHL antibody (monoclonal) (M01).
分子量	24153 Da
宿主	mouse
種屬反應(yīng)性	Human
靶點(diǎn)	VHL (NP_000542, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
克隆號(hào)	1G12
亞型	IgG2b Kappa
基因ID	7428
UniProt ID	P40337
總結(jié)	Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
形式	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IF, E
稀釋方法	WB~~1:500~1000
別名	Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
圖像	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (38.21 KDa) . Western Blot analysis of VHL expression in transfected 293T cell line by VHL monoclonal antibody (M01), clone 1G12. Lane 1: VHL transfected lysate(19.7 KDa). Lane 2: Non-transfected lysate. Immunofluorescence of monoclonal antibody to VHL on HeLa cell . [antibody concentration 10 ug/ml]
說(shuō)明書(shū)	Product Datasheet Protocol
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