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PAX5 Antibody (monoclonal) (M01)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
APR12737G 100 μg / ¥4950

PAX5 Antibody (monoclonal) (M01)

品牌

Leading Biology

貨號(hào)

APR12737G

產(chǎn)品分類(lèi)

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PAX5 antibody (monoclonal) (M01).

分子量

42149 Da

宿主

mouse

種屬反應(yīng)性

Human

靶點(diǎn)

PAX5 (NP_057953, 192 a.a. ~ 301 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

克隆號(hào)

8F9

亞型

IgG1 Kappa

基因ID

UniProt ID

總結(jié)

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

形式

Clear, colorless solution in phosphate buffered saline, pH 7.2 .

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC, E

稀釋方法

WB~~1:500~1000

別名

Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5

圖像

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .

PAX5 monoclonal antibody (M01), clone 8F9. Western Blot analysis of PAX5 expression in IMR-32.

Western Blot analysis of PAX5 expression in transfected 293T cell line by PAX5 monoclonal antibody (M01), clone 8F9. Lane 1: PAX5 transfected lysate(42.1 KDa). Lane 2: Non-transfected lysate.

說(shuō)明書(shū)

數(shù)量

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