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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide

S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide

貨號 貨期 規(guī)格 / 價格 詢價
APG03093G 100 μg / ¥4950

S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide

品牌

Leading Biology

貨號

APG03093G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality S100A1 (Astrocyte Marker) antibody - Without BSA and Azide.

分子量

10-12kDa

細胞定位

Antigen Cellular Localization: Cytoplasm.

宿主

Mouse

種屬反應(yīng)性

Human, Mouse, Rat, Cow

克隆號

4C4.9 + S100A1/1012

亞型

Mouse / IgG's

通用名

S100A

基因ID

UniProt ID

功能

Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

總結(jié)

S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein. Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas and their metastases.

形式

Liquid

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IF, FC

別名

Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100A1, S100A

圖像

Formalin--paraffin human Melanoma stained with S100A1 Monoclonal Antibody (4C4.9 + S100A1/1012)

Confocal Immunofluorescent analysis of A2058 cellsusing AF488-labeled S100A1 Monoclonal Antibody (4C4.9 + S100A1/1012) (Green).F-actin filaments were labeled with DyLight 554 Phalloidin (red).DAPI was used to stain the cell nuclei (blue).

Confocal Immunofluorescent analysis of A2058 cellsusing AF488-labeled Isotype Control Monoclonal Antibody (IgG2a) (Green).F-actin filaments were labeled with DyLight 554 Phalloidin (red).DAPI was used to stain the cell nuclei (blue). (Negative Control)

說明書

數(shù)量

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