全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APG01321G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Tyrosinase (Melanoma Marker) antibody.
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分子量 |
70-80kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Melanosome membrane; Single-pass type I membrane protein
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號(hào) |
OCA1/812
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亞型 |
Mouse / IgG2a, kappa
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基因ID |
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UniProt ID |
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功能 |
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
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總結(jié) |
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC-P, IF, FC, E
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別名 |
Tyrosinase, 1.14.18.1, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR
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圖像 |
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說明書 |
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數(shù)量 |
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