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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > IDH1 (Isocitrate Dehydrogenase) Antibody品牌 |
Leading Biology | 貨號 |
APR07377G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IDH1 (Isocitrate Dehydrogenase) antibody.
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分子量 |
45-47kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Peroxisome
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號 |
IDH1/1152
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亞型 |
Mouse / IgG1, kappa
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通用名 |
PICD
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基因ID |
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UniProt ID |
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總結(jié) |
It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ? ?-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ? ?-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, IF, FC
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別名 |
Isocitrate dehydrogenase [NADP] cytoplasmic, IDH, 1.1.1.42, Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, IDH1, PICD
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圖像 |
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說明書 |
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數(shù)量 |
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