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STAT1 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR10259G 100 μl / ￥4950

STAT1 Antibody

品牌

 Leading Biology

貨號(hào)

 APR10259G

產(chǎn)品分類

 Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STAT1 antibody.

分子量
91 KDa

細(xì)胞定位
Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4

宿主
Mouse

種屬反應(yīng)性
Human

基因ID

UniProt ID

功能
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

總結(jié)
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

形式
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IP

稀釋方法
WB~~1:1000 IP~~1:500

別名
Signal transducer and activator of transcription 1 91kD;DKFZp686B04100;ISGF 3;ISGF-3;OTTHUMP00000163552;OTTHUMP00000165046; OTTHUMP00000165047;OTTHUMP00000205845;Signal transducer and activator of transcription 1 91kDa;Signal transducer and activator of transcription 1 alpha/beta;Signal transducer and activator of transcription 1;Signal transducer and activator of transcription 1, 91kD; Signal transducer and activator of transcription 1-alpha/beta;Signal Transductor and Activator of Transcription 1;STAT 1;STAT 91;Stat1; STAT1_HUMAN;STAT91;Transcription factor ISGF 3 components p91 p84;Transcription factor ISGF-3 components p91/p84.

圖像

Western blot detection of STAT1 in Hela,MCF7,COS7,SW480 and A549 cell lysates using STAT1 mouse mAb (1:1000 diluted).Predicted band size:91KDa.Observed band size:91KDa.

Immunoprecipitation analysis of Hela cell lysates using STAT1 mouse mAb.

說(shuō)明書

數(shù)量

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