NOTCH3 Antibody (C-term Q2306)

AMM06757G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM06757G		100 μl / ￥4950

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NOTCH3 Antibody (C-term Q2306)

品牌	Leading Biology	貨號	AMM06757G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NOTCH3 antibody (C-term Q2306).
分子量	243631 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein
宿主	Mouse
種屬反應(yīng)性	Human
免疫原	2291-2321 aa
靶點(diǎn)	This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
克隆號	487CT6.9.2
亞型	IgG1
基因ID	4854
UniProt ID	Q9UM47
功能	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
總結(jié)	This gene encodes the third discovered human homologue ofthe Drosophilia melanogaster type I membrane protein notch. InDrosophilia, notch interaction with its cell-bound ligands (delta,serrate) establishes an intercellular signalling pathway that playsa key role in neural development. Homologues of the notch-ligandshave also been identified in human, but precise interactionsbetween these ligands and the human notch homologues remains to bedetermined. Mutations in NOTCH3 have been identified as theunderlying cause of cerebral autosomal dominant arteriopathy withsubcortical infarcts and leukoencephalopathy (CADASIL). [providedby RefSeq].
形式	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:100~250
別名	Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3
圖像	Anti-NOTCH3 Antibody at 1:2000 dilution + Hela whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 250 kDa Blocking/Dilution buffer: 5% NFDM/TBST. NOTCH3 Antibody (Q2306) (Cat. AMM06757G) western blot analysis in Hela cell line lysates (35μg/lane).This demonstrates the NOTCH3 antibody detected the NOTCH3 protein (arrow).
說明書	Product Datasheet Protocol
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