DDR2 Antibody(Ascites)

APR11715G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR11715G		0.1 ml / ￥4950

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安諾倫（北京）生物科技有限公司

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DDR2 Antibody(Ascites)

品牌	Leading Biology	貨號(hào)	APR11715G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DDR2 antibody(Ascites).
分子量	96736 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Single- pass type I membrane protein
宿主	Mouse
種屬反應(yīng)性	Human
免疫原	290-320 aa
靶點(diǎn)	This DDR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from human DDR2.
克隆號(hào)	484CT5.5.4
亞型	IgG1
通用名	NTRKR3, TKT, TYRO10
基因ID	4921
UniProt ID	Q16832
功能	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
總結(jié)	Receptor tyrosine kinases (RTKs) play a key role in thecommunication of cells with their microenvironment. These moleculesare involved in the regulation of cell growth, differentiation, andmetabolism. In several cases the biochemical mechanism by whichRTKs transduce signals across the membrane has been shown to beligand induced receptor oligomerization and subsequentintracellular phosphorylation. This autophosphorylation leads tophosphorylation of cytosolic targets as well as association withother molecules, which are involved in pleiotropic effects ofsignal transduction. RTKs have a tripartite structure withextracellular, transmembrane, and cytoplasmic regions. This geneencodes a member of a novel subclass of RTKs and contains adistinct extracellular region encompassing a factor VIII-likedomain. Alternative splicing in the 5' UTR results in multipletranscript variants encoding the same protein. [provided byRefSeq].
形式	Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:100~1600
別名	Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, DDR2, NTRKR3, TKT, TYRO10
圖像	DDR2 Antibody (Cat. APR11715G) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the DDR2 antibody detected the DDR2 protein (arrow).
說(shuō)明書	Product Datasheet Protocol
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