MYOG Antibody (N-term) (ascites)

APR17514G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17514G		0.1 ml / ￥4950

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安諾倫（北京）生物科技有限公司

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MYOG Antibody (N-term) (ascites)

品牌	Leading Biology	貨號	APR17514G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MYOG antibody (N-term) (ascites).
分子量	25037 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin- remodeling and transcription initiation in developing embryos
宿主	Mouse
種屬反應(yīng)性	Mouse
免疫原	30-58 aa
靶點(diǎn)	This MYOG antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 30-58 amino acids from the N-terminal region of human MYOG.
克隆號	304CT11.6.1
亞型	IgG1
通用名	BHLHC3, MYF4
基因ID	4656
UniProt ID	P15173
功能	Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).
總結(jié)	Myogenin is a muscle-specific transcription factor thatcan induce myogenesis in a variety of cell types in tissue culture.It is a member of a large family of proteins related by sequencehomology, the helix-loop-helix (HLH) proteins. It is essential forthe development of functional skeletal muscle. [provided byRefSeq].
形式	Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000~4000
別名	Myogenin, Class C basic helix-loop-helix protein 3, bHLHc3, Myogenic factor 4, Myf-4, MYOG, BHLHC3, MYF4
圖像	MYOG Antibody (N-term) (Cat. APR17514G) western blot analysis in mouse heart tissue lysates (35μg/lane).This demonstrates the MYOG antibody detected the MYOG protein (arrow).
說明書	Product Datasheet Protocol
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