品牌 |
Leading Biology | 貨號(hào) |
APR12739G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PAX6 antibody (Ascites).
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分子量 |
46683 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6.
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克隆號(hào) |
193CT15.2.2
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亞型 |
IgM,K
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通用名 |
AN2
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基因ID |
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UniProt ID |
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功能 |
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
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總結(jié) |
This gene encodes paired box gene 6, one of many humanhomologs of the Drosophila melanogaster gene prd. In addition tothe hallmark feature of this gene family, a conserved paired boxdomain, the encoded protein also contains a homeo box domain. Bothdomains are known to bind DNA, and function as regulators of genetranscription. This gene is expressed in the developing nervoussystem, and in developing eyes. Mutations in this gene are known tocause ocular disorders such as aniridia and Peter's anomaly.Alternatively spliced transcript variants encoding either the sameor different isoform have been found for this gene. [provided byRefSeq].
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形式 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF, E
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稀釋方法 |
WB~~1:500~16000
IF~~1:10~50
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別名 |
Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2
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圖像 |
PAX6 (Cat. APR12739G) western blot analysis in 293 cell line lysates (35μg/lane).This demonstrates the PAX6 antibody detected the PAX6 protein (arrow). Confocal immunofluorescent analysis of PAX6 Antibody (Ascites)( APR12739G) with Hela cell followed by Alexa Fluor? 488-conjugated goat anti-mouse lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue). |
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說明書 |
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數(shù)量 |
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