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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > CD104 (Integrin Beta-4) (Squamous Cell Carcinoma Antigen) Antibody - With BSA and Azide品牌 |
Leading Biology | 貨號 |
APR14431G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD104 (Integrin Beta-4) (Squamous Cell Carcinoma Antigen) antibody - With BSA and Azide.
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分子量 |
205kDa
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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靶點 |
Human squamous cell carcinoma (UM-SCC1)
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克隆號 |
UM-A9
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亞型 |
IgG2a, kappa
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基因ID |
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UniProt ID |
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功能 |
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
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總結(jié) |
Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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形式 |
0.5 ml at 200ug/ml with BSA and azide
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, IF, FC, IP, E
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別名 |
Integrin beta-4, GP150, CD104, ITGB4
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說明書 |
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數(shù)量 |
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