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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > PLGF (Placental Growth Factor) Antibody - With BSA and Azide品牌 |
Leading Biology | 貨號(hào) |
AMP00015G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PLGF (Placental Growth Factor) antibody - With BSA and Azide.
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分子量 |
18kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
Recombinant human PLGF protein
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克隆號(hào) |
PLGF94
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亞型 |
IgG1, kappa
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通用名 |
PGFL, PLGF
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基因ID |
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UniProt ID |
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功能 |
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
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總結(jié) |
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Like VEGF, several PlGF vari- ants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PlGF signaling. While VEGF homodimers and VEGF/PlGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PlGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PlGF. VEGF and PlGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.
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形式 |
0.5 ml at 200ug/ml with BSA and azide
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
E
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別名 |
Placenta growth factor, PlGF, PGF, PGFL, PLGF
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說明書 |
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數(shù)量 |
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