TCF-3 Antibody

AMM08126G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM08126G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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TCF-3 Antibody

品牌	Leading Biology	貨號	AMM08126G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TCF-3 antibody.
分子量	62631 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus.
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	A synthetic peptide corresponding to residues in human TCF-3 was used as an immunogen.
克隆號	EPR2031
通用名	TCF3
基因ID	83439
UniProt ID	Q9HCS4
功能	Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
總結(jié)	T-cell factor 3 (transcription factor 7-like 1, TCF-3) is a component of the Wnt signaling pathway, which functions in CNS patterning, proliferation and neurogenesis, and a dominant downstream effector in embryonic stem cells (ESCs). TCF-3 binds to and represses the Oct4 promoter, and plays an important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development (1, 2). TCF-3 is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. It down-regulates NQO1, leading to increased mitomycin c resistance. It is detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium (2).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
稀釋方法	WB~~1:1000~5000
別名	Transcription factor 7-like 1, HMG box transcription factor 3, TCF-3, TCF7L1, TCF3
圖像	A. Western blot analysis on (A) A431 and (B) fetal small intestine lysates using anti-TCF-3 RabMAb (Cat. AMM08126G), dilution 1:2000.
說明書	Product Datasheet Protocol
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