Synapsin I Antibody Phospho (pS9)

APR13611G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR13611G		100 μl / ￥5450

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Synapsin I Antibody Phospho (pS9)

品牌	Leading Biology	貨號(hào)	APR13611G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Synapsin I antibody Phospho (pS9).
分子量	74111 Da
細(xì)胞定位	Antigen Cellular Localization: Cell junction, synapse. Golgi apparatus
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic phospho-peptide corresponding to residues surrounding serine 9 of human synapsin I protein.
克隆號(hào)	EP2162Y
基因ID	6853
UniProt ID	P17600
功能	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
總結(jié)	Synapsin I is a member of neuron-specific phosphoproteins that associate with synaptic vesicles (1). Three mammalians synapsins have been identified, Synapsin I, II and III. Generated by differential splicing, Synapsin Ia and Synapsin Ib differ in their Carboxyl termini (2). Synapsin I also functions in binding synaptic vesicles to several elements of the cytoskeleton including actin filaments, microtubules and spectrin. (3) Fairly abundant protein of the brain (0.4%), Synapsin I is best known to be CaM kinase II substrate in addition to cAMP-dependent protein kinase. (4) Phosphorylation at site Ser 566 and Ser 603 by CaM kinase II will cause a 5 fold decrease in the affinity of synaptic vesicles binding. A phosphorylation of serine 9 on synapsin amino-terminal can lead to inhibition in its binding to phospholipids and dissociation of synapsins from synaptic vesicles.
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:2000~5000 IHC~~1:250~500
別名	Synapsin-1, Brain protein 41, Synapsin I, SYN1
圖像	A. Western blot analysis on human brain tissue lysates using anti-Phospho-Synapsin I (pS9) RabMAb (Cat. APR13611G), 1:5000 dilution. Cells were either (A) untreated (B) treated with AP B. Immunohistochemical analysis of paraffin-embedded human brain using anti-phospho Synapsin (pS9) RabMAb (Cat. APR13611G).
說明書	Product Datasheet Protocol
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