Cytokeratin-17 Antibody (C-term)

APR15664G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR15664G		100 μl / ￥5450

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Cytokeratin-17 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	APR15664G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Cytokeratin-17 antibody (C-term).
分子量	48106 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm {ECO:0000250\|UniProtKB:Q9QWL7}.
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	A synthetic peptide corresponding to residues on the C-terminus of human CK-17 was used as an immunogen.
克隆號(hào)	EPR1624Y
基因ID	3872
UniProt ID	Q04695
功能	Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
總結(jié)	Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). CK 17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, IF
稀釋方法	WB~~1:1000~10000 IHC~~1:50~100
別名	Keratin, type I cytoskeletal 17, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17
圖像	A. Western blot analysis on HeLa cell lysate using anti-CK-17 RabMAb (Cat. APR15664G), dilution 1:10,000. B. Immunohistochemical analysis of paraffin-embedded human squamous cervical carcinoma using anti-CK-17 RabMAb (Cat. APR15664G). C. Immunofluorescent staining of A431 cells using anti-CK-17 RabMAb (Cat. APR15664G).
說明書	Product Datasheet Protocol
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