Functional APRIL (mouse) Antibody, mAb (recombinant) (blocking)

AMP00001G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMP00001G		100 μg / ￥5450

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Functional APRIL (mouse) Antibody, mAb (recombinant) (blocking)

品牌	Leading Biology	貨號	AMP00001G
產(chǎn)品分類	Monoclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Functional APRIL (mouse) Antibody, mAb (recombinant) (blocking).
分子量	26889 Da
細胞定位	Antigen Cellular Localization: Secreted.
宿主	Purified From?HEK 293 Cell?culture Supernatant.
種屬反應性	Mouse
靶點	Recognizes mouse APRIL. Does not recognize mouse BAFF.
克隆號	Apry-1-1
亞型	Mouse IgG2bλ
通用名	April
基因ID	69583
UniProt ID	Q9D777
功能	Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
總結	APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth and is involved in monocyte/macrophage-mediated immunological processes.Anti-APRIL (mouse) Monoclonal Antibody (recombinant) (Blocking) (APRY-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
形式	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	E, IP
圖像	Binding of APRIL (mouse) to BCMA is inhibited by anti-APRIL (mouse), mAb (rec.) (blocking) (APRY-1-1).BCMA:Fc was coated on an ELISA plate at 1ug /ml. anti-APRIL (mouse) mAb (rec.) (blocking) (APRY-1-1) or an unrelated mAb (recombinant) (Negative control) were added (starting at 50ug/ml with a twofold serial dilution) together with 0.1ug /ml of MegaAPRIL (mouse). After incubation for 1 h at RT, the MegaAPRIL (mouse) binding was detected using an anti-FLAG antibody (HRP). The percentage of binding is shown.
說明書	Product Datasheet Protocol
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Functional APRIL (mouse) Antibody, mAb (recombinant) (blocking)