Cyr61/CCN1 Antibody (Clone 466305)

AMRa00001G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMRa00001G		50 μg / ￥5450

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Cyr61/CCN1 Antibody (Clone 466305)

品牌	Leading Biology	貨號	AMRa00001G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Cyr61/CCN1 Antibody (Clone 466305).
分子量	41709 Da
細(xì)胞定位	Antigen Cellular Localization: Secreted.
宿主	Rat
靶點	Cyr61/CCN1
克隆號	466305
亞型	Rat IgG2B
通用名	Ccn1, Igfbp10
基因ID	16007
UniProt ID	P18406
功能	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down- regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
總結(jié)	Cyr61 is a member of angiogenic and vasculogenic regulators designated CCN proteins, which includes CTGF, Cyr61 homolog, Fisp2. Cyr61 functions as an angiogenic inducer, stimulating cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Elevated expression of Cyr61 is observed during vessel growth, wound healing and chondrocyte differentiation.
形式	Liquid
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
圖像	Cyr61/CCN1 in Mouse Trigeminal Ganglia. Cyr61/CCN1 was detected in perfusion fixed frozen sections of mouse trigeminal ganglia using 25 μg/mL Cyr61/CCN1 Antibody O/N at 4 °C. Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit and counterstained with hematoxylin (blue). Detection of Mouse Cyr61 by Western Blot. Western blot shows lysates of mouse brain tissue (negative control) and mouse heart tissue. PVDF membrane was probed with 2 μg/mL of Cyr61/CCN1 Antibody followed by HRP-conjugated Anti-Rat IgG Secondary Antibody Specific bands were detected for Cyr61 (at approximately 50 kDa) and cleaved Cyr61 (at approximately 25 kDa).
說明書	Product Datasheet Protocol
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