全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM02611G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EphA1 Antibody.
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分子量 |
108kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號 |
5D2
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亞型 |
IgG1
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通用名 |
EPH, EPHT, EPHT1
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基因ID |
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UniProt ID |
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功能 |
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, E
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稀釋方法 |
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
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圖像 |
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說明書 |
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數(shù)量 |
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