Functional IL-1R2 (mouse) Antibody, mAb (recombinant)

AMP00009G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMP00009G		100 μg / ￥5450

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Functional IL-1R2 (mouse) Antibody, mAb (recombinant)

品牌	Leading Biology	貨號	AMP00009G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Functional IL-1R2 (mouse) Antibody, mAb (recombinant).
分子量	45645 Da
細胞定位	Antigen Cellular Localization: Membrane; Single-pass type I membrane protein. Cell membrane. Secreted
宿主	Purified From?HEK 293 Cell?culture Supernatant.
種屬反應(yīng)性	Mouse
靶點	Recognizes mouse IL-1R2.
克隆號	Praxy-1-1
亞型	Mouse IgG2bλ
通用名	Il-1r2, Il1rb
基因ID	16178
UniProt ID	P27931
功能	Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).
總結(jié)	The inflammatory actions of IL-1α and -β- depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.
形式	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	FC, E
圖像	Detection of endogenous mouse IL-1R2 with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) . Method: In vitro-cultivated BMN (mouse Neutrophils) (stimulated 24h with hydrocortisone) were stained with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) (thick green line) or an isotype control (thin black line) at 5ug/ml each, revealed with a secondary anti-mouse antibody (FITC) and then analyzed by flow cytometry.
說明書	Product Datasheet Protocol
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