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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > LMNA / Lamin A/C Antibody (clone 133A2)品牌 |
Leading Biology | 貨號 |
AMM02262G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LMNA / Lamin A/C Antibody (clone 133A2).
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分子量 |
74139 Da
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細胞定位 |
Antigen Cellular Localization:
Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse, Rat, Bovine, Dog
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靶點 |
Recognizes an epitope located between residues 598-611 of lamin A and therefore reacts exclusively with lamin A.
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克隆號 |
133A2
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亞型 |
IgG3
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通用名 |
LMN1
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基因ID |
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UniProt ID |
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功能 |
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
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總結(jié) |
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, ICC, IHC-Fr, Flo
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稀釋方法 |
Flo (1:100 - 1:200), IHC-Fr (1:100 - 1:200), IHC-P (10 μg/ml), WB (1:100 - 1:1000),
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圖像 |
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說明書 |
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數(shù)量 |
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