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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody - Without BSA and Azide

Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody - Without BSA and Azide

貨號 貨期 規(guī)格 / 價格 詢價
AMM00766G 100 μg / ¥4950

Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody - Without BSA and Azide

品牌

Leading Biology

貨號

AMM00766G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody - Without BSA and Azide.

分子量

67kDa

細胞定位

Antigen Cellular Localization: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side

宿主

Mouse

種屬反應(yīng)性

Human

克隆號

1G12

亞型

Mouse / IgG1, kappa

通用名

OCI5

基因ID

UniProt ID

功能

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.

總結(jié)

Recognizes a protein, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4.? HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

形式

Liquid

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

IHC, IF, FC

圖像

Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with Glypican-3 Monoclonal Antibody (1G12)

說明書

數(shù)量

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