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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Cyclin D1 (G1-Cyclin & Mantle Cell Marker)Mouse Monoclonal Antibody [Clone CCND1/809]品牌 |
Leading Biology | 貨號 |
AMM00206G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Cyclin D1 (G1-Cyclin & Mantle Cell Marker)Mouse Monoclonal Antibody [Clone CCND1/809] .
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分子量 |
36kDa
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細胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members
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宿主 |
Mouse
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種屬反應性 |
Human
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靶點 |
Recombinant full-length human CCND1 protein
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克隆號 |
CCND1/809
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亞型 |
IgG2a, kappa
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通用名 |
BCL1, PRAD1
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基因ID |
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UniProt ID |
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功能 |
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
IF, FC
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圖像 |
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說明書 |
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數(shù)量 |
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