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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody品牌 |
Leading Biology | 貨號(hào) |
AMM01538G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody.
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分子量 |
105-120kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Isoform 1: Cell membrane; Single-pass type I membrane protein
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號(hào) |
Ki-1/779
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亞型 |
Mouse / IgG1, kappa
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通用名 |
CD30, D1S166E
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基因ID |
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UniProt ID |
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功能 |
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.
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總結(jié) |
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkinā€?s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC, IF, FC
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圖像 |
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說明書 |
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數(shù)量 |
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