亚洲成人aⅴ综合_男人的天堂网址在线观看_日韩国产精品欧美尤物一区二区_超级性按摩中文字幕一级不长_在线观看精品国产福利片2019_中文字幕邻居人妻_最新流露出of高能预警CDwant_粉色视频高清视频版全集_产自拍视频在线_亚洲AV永久无码精品桃花岛知道

您好,歡迎光臨安諾倫(北京)生物科技商城!
全國(guó)服務(wù)熱線:400-965-8633
關(guān)注我們
  • 會(huì)員中心
  • 會(huì)員中心
    詢價(jià)列表
    0

    最新加入的商品

    0 件商品 合計(jì):¥ 0
  • 會(huì)員中心
    購物車

    最新加入的商品

    件商品 合計(jì):¥ 0

全部產(chǎn)品分類

自主品牌
當(dāng)前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > VEGFR3 Antibody

VEGFR3 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM02472G 100μl / ¥4950

VEGFR3 Antibody

品牌

Leading Biology

貨號(hào)

AMM02472G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality VEGFR3 Antibody.

分子量

152757 Da

細(xì)胞定位

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization Isoform 2: Cell membrane; Single-pass type I membrane protein

宿主

Mouse

種屬反應(yīng)性

Human

免疫原

1-439 aa

靶點(diǎn)

Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.

克隆號(hào)

818CT12.1.1

亞型

IgG2a

通用名

VEGFR3

基因ID

UniProt ID

功能

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr- 185', and of AKT1 at 'Ser-473'.

總結(jié)

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, FC, IHC-P, E

稀釋方法

IHC-P~~1:25 FC~~1:25 WB~~1:2000

圖像

Immunohistochemical analysis of paraffin-embedded H. testis section using VEGFR3(AMM02472G). was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.

Flow cytometric analysis of HUVEC cells using VEGFR3(green, AMM02472G) compared to an isotype control of mouse IgG2a(blue). AMM02472G was diluted at 1:25 dilution. An Alexa Fluor? 488 goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody.

Immunohistochemical analysis of paraffin-embedded H. kidney section using VEGFR3( AMM02472G). was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.

說明書

數(shù)量

相關(guān)產(chǎn)品

選擇 品牌 貨號(hào) 產(chǎn)品名稱 規(guī)格 分類 研究領(lǐng)域 說明書 數(shù)量 目錄價(jià)
1 Leading Biology APG01369G VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide 100 μg Monoclonal Antibodies
¥4950.00 訂購 詢價(jià)
2 Leading Biology AMM07627G RIN2 Antibody (monoclonal) (M01) 100 μg Monoclonal Antibodies
¥4950.00 訂購 詢價(jià)
3 Leading Biology APR15980G FGG Antibody 100 μl Monoclonal Antibodies
¥5450.00 訂購 詢價(jià)
4 Leading Biology AMM05161G GOB5 / CLCA1 Antibody (clone 1C4) 50 μg Monoclonal Antibodies
¥5450.00 訂購 詢價(jià)
5 Leading Biology APR17667G ORAI1 Antibody [3F6H5] 0.1 mg Monoclonal Antibodies
¥6950.00 訂購 詢價(jià)
6 Leading Biology APR11118G HIV-1 p24 Antibody [7F4] (biotin) 0.1 mg Monoclonal Antibodies
¥6950.00 訂購 詢價(jià)

產(chǎn)品添加成功!

購物車已有 0 件產(chǎn)品

加入詢價(jià)單成功!

詢價(jià)單已有 0 件產(chǎn)品