全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM02434G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDKN1A Antibody (C-term).
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分子量 |
18119 Da
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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免疫原 |
117-146 aa
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靶點 |
This CDKN1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the C-terminal region of human CDKN1A.
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克隆號 |
592CT11.4.4
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亞型 |
IgG1
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通用名 |
CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WA
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基因ID |
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UniProt ID |
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功能 |
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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總結(jié) |
This gene encodes a potent cyclin-dependent kinaseinhibitor. The encoded protein binds to and inhibits the activityof cyclin-CDK2 or -CDK4 complexes, and thus functions as aregulator of cell cycle progression at G1. The expression of thisgene is tightly controlled by the tumor suppressor protein p53,through which this protein mediates the p53-dependent cell cycle G1phase arrest in response to a variety of stress stimuli. Thisprotein can interact with proliferating cell nuclear antigen(PCNA), a DNA polymerase accessory factor, and plays a regulatoryrole in S phase DNA replication and DNA damage repair. This proteinwas reported to be specifically cleaved by CASP3-like caspases,which thus leads to a dramatic activation of CDK2, and may beinstrumental in the execution of apoptosis following caspaseactivation. Multiple alternatively spliced variants have been foundfor this gene.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:100~250
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圖像 |
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說明書 |
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數(shù)量 |
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