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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMM02433G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TP63 Antibody (Ascites).
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分子量 |
76785 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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免疫原 |
651-680 aa
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靶點(diǎn) |
This TP63 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from human TP63.
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克隆號(hào) |
603CT12.4.3
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亞型 |
IgM
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通用名 |
KET, P63, P73H, P73L, TP73L
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基因ID |
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UniProt ID |
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功能 |
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
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總結(jié) |
This gene encodes a member of the p53 family oftranscription factors. An animal model, p63 -/- mice, has beenuseful in defining the role this protein plays in the developmentand maintenance of stratified epithelial tissues. p63 -/- mice haveseveral developmental defects which include the lack of limbs andother tissues, such as teeth and mammary glands, which develop as aresult of interactions between mesenchyme and epithelium. Mutationsin this gene are associated with ectodermal dysplasia, and cleftlip/palate syndrome 3 (EEC3); split-hand/foot malformation 4(SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULTsyndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammarysyndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Bothalternative splicing and the use of alternative promoters resultsin multiple transcript variants encoding different proteins. Manytranscripts encoding different proteins have been reported but thebiological validity and the full-length nature of these variantshave not been determined.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:200~1600
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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