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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > TGF-alpha (Transforming Growth Factor alpha) Antibody - With BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM00189G |
產品分類 |
Monoclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TGF-alpha (Transforming Growth Factor alpha) Antibody - With BSA and Azide.
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分子量 |
~6kDa
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細胞定位 |
Antigen Cellular Localization:
Transforming growth factor alpha: Secreted, extracellular space
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宿主 |
Mouse
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種屬反應性 |
Human, Zebrafish, Rabbit
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靶點 |
A 10-amino acid synthetic peptide (aa34-43) from human TGFα.
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克隆號 |
TG86
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亞型 |
IgG1, kappa
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基因ID |
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UniProt ID |
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功能 |
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
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總結 |
This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this MAb is completely blocked by the peptide used for raising this antibody. TGFα (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC, FC, IP, E
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說明書 |
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數(shù)量 |
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