MD-2 Antibody [1A2E3]

APR17338G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17338G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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MD-2 Antibody [1A2E3]

品牌	Leading Biology	貨號(hào)	APR17338G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MD-2 antibody [1A2E3] .
分子量	18546 Da
細(xì)胞定位	Antigen Cellular Localization: Secreted, extracellular space.
宿主	Mouse
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	LY96;
克隆號(hào)	1A2E3
亞型	IgG1
通用名	ESOP1, MD2
基因ID	23643
UniProt ID	Q9Y6Y9
功能	Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
總結(jié)	MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
圖像	Western blot analysis of (A) 25 and (B) 125 ng of MD-2 recombinant protein with MD-2 antibody at 1 μg/mL. Immunohistochemistry of MD-2 in human spleen with MD-2 antibody at 2.5 μg/mL.
說(shuō)明書	Product Datasheet Protocol
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