Superoxide Dismutase 1 (SOD-1) Antibody (72B1)

APR10347G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR10347G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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Superoxide Dismutase 1 (SOD-1) Antibody (72B1)

品牌	Leading Biology	貨號	APR10347G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Superoxide Dismutase 1 (SOD-1) antibody (72B1).
分子量	15936 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria
宿主	Mouse
種屬反應(yīng)性	Human
靶點(diǎn)	SOD1
克隆號	72B1
亞型	Mouse IgG 1
基因ID	6647
UniProt ID	P00441
功能	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
總結(jié)	Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel wallsand airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. SOD1 destroys radicals which are normally produced within the cells and which are toxic to biological systems.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IP
別名	Superoxide dismutase, SOD1, SOD, ALS, ALS1, IPOA.
圖像	IP analysis of HeLa cell lysates. Lane 1: Input. Lane 2: Precipitated sample.
說明書	Product Datasheet Protocol
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Superoxide Dismutase 1 (SOD-1) Antibody (72B1)