TDP-43 / TARDBP Antibody (clone 2E2-D3)

AMM05410G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM05410G		50 μg / ￥5450

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安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
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TDP-43 / TARDBP Antibody (clone 2E2-D3)

品牌	Leading Biology	貨號(hào)	AMM05410G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TDP-43 / TARDBP antibody (clone 2E2-D3).
分子量	45kDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies
宿主	Mouse
種屬反應(yīng)性	Human
克隆號(hào)	2E2-D3
通用名	TDP43
基因ID	23435
UniProt ID	Q13148
功能	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
總結(jié)	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E, RNAi
稀釋方法	IF (10 μg/ml), IHC-P (5 μg/ml),
別名	TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43
圖像	TARDBP monoclonal antibody clone 2E2-D3 Western blot of TARDBP expression in A-431. Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell (antibody concentration 10 ug/ml). Anti-TARDBP antibody IHC of human brain, cortex.
說明書	Product Datasheet Protocol
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