YES1 Antibody

APR13990G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR13990G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
Inquiry@annoron.com

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YES1 Antibody

品牌	Leading Biology	貨號(hào)	APR13990G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality YES1 antibody.
分子量	60801 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway
宿主	Mouse
種屬反應(yīng)性	Human
克隆號(hào)	2F3E6
亞型	IgG1
通用名	YES
基因ID	7525
UniProt ID	P07947
功能	Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1/500 - 1/2000 ICC~~1:200~~1000 IF~~1:200~1000.
別名	Tyrosine-protein kinase Yes, 2.7.10.2, Proto-oncogene c-Yes, p61-Yes, YES1, YES
圖像	Figure 1: Western blot analysis using YES1 mouse mAb against truncated YES1-His recombinant protein (1) and full-length GFP-YES1(aa1-543) transfected COS7 cell lysate (2). Figure 2: Confocal immunofluorescence analysis of Hela cells using Calnexin mouse mAb (green). Figure 2: Confocal immunofluorescence analysis of Hela cells using anti-Calnexin mAb (green).
說(shuō)明書(shū)	Product Datasheet Protocol
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