TIP60 Antibody

APG02988G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APG02988G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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TIP60 Antibody

品牌	Leading Biology	貨號	APG02988G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TIP60 antibody.
分子量	58.6kDa
細胞定位	Antigen Cellular Localization: Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies
宿主	Mouse
種屬反應性	Human
克隆號	2A11H7
亞型	IgG1
通用名	HTATIP, TIP60
基因ID	10524
UniProt ID	Q92993
功能	Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IHC, FC, ICC, E
稀釋方法	E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400
別名	Histone acetyltransferase KAT5, 2.3.1.48, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, KAT5, HTATIP, TIP60
圖像	Figure 1:Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng); Figure 2:Western blot analysis using TIP60 mAb against human TIP60 (AA: 18-208) recombinant protein. (Expected MW is 47.9 kDa) Figure 3:Western blot analysis using TIP60 mAb against HEK293 (1) and TIP60 (AA: 18-208)-hIgGFc transfected HEK293 (2) cell lysate.
說明書	Product Datasheet Protocol
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