品牌 |
Leading Biology |
貨號 |
APR15380G |
產(chǎn)品分類 |
Monoclonal Antibodies |
研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDX1 antibody.
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分子量 |
28.1kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus.
|
宿主 |
Mouse
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種屬反應(yīng)性 |
Human
|
克隆號 |
1B11A9
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亞型 |
IgG2a
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基因ID |
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UniProt ID |
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功能 |
Could play a role in the terminal differentiation of the intestine.
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總結(jié) |
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. ;
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
E~~1/10000
WB~~1/500 - 1/2000
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別名 |
Homeobox protein CDX-1, Caudal-type homeobox protein 1, CDX1
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圖像 |
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 1: Western blot analysis using CDX1 mAb against human CDX1 recombinant protein. (Expected MW is 37.9 kDa)
Figure 2: Western blot analysis using CDX1 mAb against HEK293 (1) and CDX1 (AA: 122-227)-hIgGFc transfected HEK293 (2) cell lysate.
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說明書 |
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數(shù)量 |
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