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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > CREBBP / CREB Binding Protein Antibody (aa2071-2091)品牌 |
Leading Biology | 貨號 |
APG02778G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CREBBP / CREB Binding Protein antibody (aa2071-2091).
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分子量 |
265kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse, Rat, Monkey
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靶點 |
Recognizes p300 and CBP. p300 and CBP differ by three noncontiguous residues within the 21 amino acid epitope region. A difference that does not detectably affect the reactivity of This antibody. Species cross-reactivity: human, monkey, mink, mouse, ...
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通用名 |
CBP
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基因ID |
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UniProt ID |
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功能 |
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
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總結(jié) |
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC-P, IF
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稀釋方法 |
IHC-P (1:25)
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別名 |
CREB-binding protein, 2.3.1.48, CREBBP, CBP
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圖像 |
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說明書 |
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數(shù)量 |
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