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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > GOK / STIM1 Antibody (C-Terminus, clone CDN3H4)品牌 |
Leading Biology | 貨號(hào) |
AMM05163G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GOK / STIM1 antibody (C-Terminus, clone CDN3H4).
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分子量 |
77kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
Synthesized peptide (C-terminal cytoplasmic part of STIM1).
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克隆號(hào) |
CDN3H4
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通用名 |
GOK
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基因ID |
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UniProt ID |
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功能 |
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
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總結(jié) |
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, ICC, IP
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稀釋方法 |
IHC-P (5 μg/ml), WB (1 μg/ml),
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別名 |
Stromal interaction molecule 1, STIM1, GOK
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圖像 |
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說(shuō)明書 |
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數(shù)量 |
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